Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis

Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis

Abstract The choroid plexus (CP) is a key regulator of the central nervous system (CNS) homeostasis through its secretory, immunological and barrier properties. Accumulating evidence suggests that the CP plays a pivotal role in the pathogenesis of multiple sclerosis (MS), but the underlying mechanis...

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Bibliographic Details
Main Authors: Sabela Rodríguez-Lorenzo, David Miguel Ferreira Francisco, Ricardo Vos, Bert van het Hof, Merel Rijnsburger, Horst Schroten, Hiroshi Ishikawa, Wissam Beaino, Rémy Bruggmann, Gijs Kooij, Helga E. de Vries
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Acta Neuropathologica Communications
Subjects:
Choroid plexus
Multiple sclerosis (MS)
RNA-sequencing
Cerebrospinal fluid (CSF)
Hypoxia
PAI-1
Online Access:http://link.springer.com/article/10.1186/s40478-020-00903-y

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http://link.springer.com/article/10.1186/s40478-020-00903-y

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