Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

Abstract Background Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant. Methods We whole-genome sequen...

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Bibliographic Details
Main Authors: Carolien Ruesen, Lidya Chaidir, Arjan van Laarhoven, Sofiati Dian, Ahmad Rizal Ganiem, Hanna Nebenzahl-Guimaraes, Martijn A. Huynen, Bachti Alisjahbana, Bas E. Dutilh, Reinout van Crevel
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Genomics
Subjects:
Pulmonary tuberculosis
Tuberculous meningitis
Whole genome sequencing
Homoplasy
Online Access:http://link.springer.com/article/10.1186/s12864-018-4498-z

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http://link.springer.com/article/10.1186/s12864-018-4498-z

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