ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

Protective immune responses depend on the formation of immune synapses between T cells and antigen-presenting cells (APCs). The two main LFA-1 ligands, ICAM-1 and ICAM-2, are co-expressed on many cell types, including APCs and blood vessels. Although these molecules were suggested to be key players...

Full description

Bibliographic Details
Main Authors: Sara W. Feigelson, Adam Solomon, Adi Biram, Miki Hatzav, Moria Lichtenstein, Ofer Regev, Stav Kozlovski, Diana Varol, Caterina Curato, Dena Leshkowitz, Steffen Jung, Ziv Shulman, Ronen Alon
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
T cell activation
adaptive immunity
vaccination
antigens
differentiation
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319551

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717319551

Similar Items