Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis

Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis

Objectives: The streptozotocin (STZ) model is widely used in diabetes research. However, the cellular and molecular states of pancreatic endocrine cells in this model remain unclear. This study explored the molecular characteristics of islet cells treated with STZ and re-evaluated β-cell dysfunction...

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Bibliographic Details
Main Authors: Ye Feng, Wei-Lin Qiu, Xin-Xin Yu, Yu Zhang, Mao-Yang He, Lin-Chen Li, Li Yang, Weiyi Zhang, Michael Franti, Junqing Ye, Joerg D. Hoeck, Cheng-Ran Xu
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Molecular Metabolism
Subjects:
β-cell heterogeneity
Streptozotocin (STZ) model
Single-cell RNA-sequencing
Trans-differentiation
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300569

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http://www.sciencedirect.com/science/article/pii/S2212877820300569

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