A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation

A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation

Rationale: Decreased expression and activity of endothelial nitric oxide synthase (eNOS) in response to inflammatory and metabolic insults is the hallmark of endothelial cell (EC) dysfunction that preludes the development of atherosclerosis and hypertension. We previously reported the atheroprotecti...

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Bibliographic Details
Main Authors: Cleide Angolano, Elzbieta Kaczmarek, Sanah Essayagh, Soizic Daniel, Lynn Y. Choi, Brian Tung, Gabriel Sauvage, Andy Lee, Franciele C. Kipper, Maria B. Arvelo, Herwig P. Moll, Christiane Ferran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
A20/TNFAIP3
endothelial nitric oxidase synthase
inflammation
Kruppel-like factor 2
atherosclerosis
endothelial cell dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.651230/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.651230/full

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