The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.

The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.

The TGF-β/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall system is unknown. In this work, we used computational and experimental methods...

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Bibliographic Details
Main Authors: Junjie Wang, Lisa Tucker-Kellogg, Inn Chuan Ng, Ruirui Jia, P S Thiagarajan, Jacob K White, Hanry Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4105941?pdf=render

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http://europepmc.org/articles/PMC4105941?pdf=render

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