Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression

Abstract Background Nuclear translocation of several oncogenic proteins have previously been reported, but neither the translocation of doublecortin (DCX) nor the mechanism involved has been studied. DCX is a neuronal microtubule-associated protein (MAP) that is crucial for adult neurogenesis and ne...

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Main Authors: Abiola Abdulrahman Ayanlaja, Guanquan Ji, Jie Wang, Yue Gao, Bo Cheng, Kouminin Kanwore, Lin Zhang, Ye Xiong, Piniel Alphayo Kambey, Dianshuai Gao
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Cell Communication and Signaling
Subjects:
Doublecortin (DCX)
Glioblastoma Multiforme (GBM)
RanGTPase pathway
Nucleocytoplasmic transport
Classical nuclear localization signals (cNLS)
Online Access:https://doi.org/10.1186/s12964-019-0485-5

Internet

https://doi.org/10.1186/s12964-019-0485-5

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