Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors

Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors

Abstract Background The clinical success of immune checkpoint inhibitors demonstrates that reactivation of the human immune system delivers durable responses for some patients and represents an exciting approach for cancer treatment. An important class of preclinical in vivo models for immuno-oncolo...

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Bibliographic Details
Main Authors: Wenyan Zhong, Jeremy S. Myers, Fang Wang, Kai Wang, Justin Lucas, Edward Rosfjord, Judy Lucas, Andrea T. Hooper, Sharon Yang, Lu Anna Lemon, Magali Guffroy, Chad May, Jadwiga R. Bienkowska, Paul A. Rejto
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Genomics
Subjects:
Syngeneic model
Mutations
Cytolytic activity
Proteomics
Immune infiltration
Neoantigen
Online Access:https://doi.org/10.1186/s12864-019-6344-3

Internet

https://doi.org/10.1186/s12864-019-6344-3

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