ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

Gangliosides are glycosphingolipids, which are abundant in brain, are known to modulate ion channels and cell-to-cell communication. Deficiencies can result in aberrant myelination and altered immune responses, which can give rise to neurodevelopmental psychiatric disorders. However, to date, little...

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Bibliographic Details
Main Authors: Tatyana Strekalova, Evgeniy Svirin, Ekaterina Veniaminova, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W.Y. Yung, Andrey Proshin, Susanne Walitza, Daniel C. Anthony, Lee Wei Lim, Klaus-Peter Lesch, Eugene D. Ponomarev
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)
Major brain gangliosides
Autism spectrum disorder (ASD)
Aggression
Proteolipid protein 1 (Plp1)
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354621001095

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http://www.sciencedirect.com/science/article/pii/S2666354621001095

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