Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

Iron-sulfur (Fe-S) clusters are ubiquitous cofactors composed of iron and inorganic sulfur. They are required for the function of proteins involved in a wide range of activities, including electron transport in respiratory chain complexes, regulatory sensing, photosynthesis and DNA repair. The prote...

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Bibliographic Details
Main Author: Tracey A. Rouault
Format: Article
Language:English
Published: The Company of Biologists 2012-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/5/2/155