Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?

Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?

Prothrombotic states, similar to heparin-induced thrombocytopenia (HIT) in recipients of the ChAdOx vaccine, sounded alarm bells internationally. Equivalent episodes of HIT were detailed in several case reports of coronavirus disease 2019. This suggests a common pathogenesis and warrants a shift in...

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Bibliographic Details
Main Authors: A. AbdelMassih, R. Hozaien, M. El Shershaby, A. Kamel, H-A Ismail, R. Fouda
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:New Microbes and New Infections
Subjects:
Adenovirus mediated vaccines
avoidance of heparin related anticoagulants
ChAdOx vaccine
COVID-19
PF4 antibodies
thrombotic thrombocytopenic purpura
Online Access:http://www.sciencedirect.com/science/article/pii/S2052297521000482

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http://www.sciencedirect.com/science/article/pii/S2052297521000482

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