Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.

The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are involved in a...

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Bibliographic Details
Main Authors: Julien Lancelot, Stéphanie Caby, Florence Dubois-Abdesselem, Mathieu Vanderstraete, Jacques Trolet, Guilherme Oliveira, Franz Bracher, Manfred Jung, Raymond J Pierce
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3772001?pdf=render

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http://europepmc.org/articles/PMC3772001?pdf=render

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