LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias[S]

LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias[S]

We report the design of a targeted resequencing panel for monogenic dyslipidemias, LipidSeq, for the purpose of replacing Sanger sequencing in the clinical detection of dyslipidemia-causing variants. We also evaluate the performance of the LipidSeq approach versus Sanger sequencing in 84 patients wi...

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Bibliographic Details
Main Authors: Christopher T. Johansen, Joseph B. Dubé, Melissa N. Loyzer, Austin MacDonald, David E. Carter, Adam D. McIntyre, Henian Cao, Jian Wang, John F. Robinson, Robert A. Hegele
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
next generation sequencing
DNA diagnosis
familial dyslipidemia
Sanger sequencing
mutations
genetic risk score
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520376653

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http://www.sciencedirect.com/science/article/pii/S0022227520376653

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