Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

Network vulnerability-based and knowledge-guided identification of microRNA biomarkers indicating platinum resistance in high-grade serous ovarian cancer

Abstract Background High-grade serous ovarian cancer (HGSC), the most common ovarian carcinoma type, is associated with the highest mortality rate among all gynecological malignancies. As chemoresistance has been demonstrated as the major challenge in improving the prognosis of HGSC patients, we her...

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Bibliographic Details
Main Authors: Xin Qi, Chunjiang Yu, Yi Wang, Yuxin Lin, Bairong Shen
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Clinical and Translational Medicine
Subjects:
miRNA biomarker
Platinum resistance
Ovarian cancer
miRNA-mRNA regulatory network
Bioinformatics model
Online Access:http://link.springer.com/article/10.1186/s40169-019-0245-6

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http://link.springer.com/article/10.1186/s40169-019-0245-6

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