Novel <span style="font-variant: small-caps">d</span>-Annulated Pentacyclic Steroids: Regioselective Synthesis and Biological Evaluation in Breast Cancer Cells

Novel <span style="font-variant: small-caps">d</span>-Annulated Pentacyclic Steroids: Regioselective Synthesis and Biological Evaluation in Breast Cancer Cells

The acid-catalyzed cyclization of benzylidenes based on 16-dehydropregnenolone acetate (16-DPA) was studied. It was found that these compounds readily undergo regioselective interrupted Nazarov cyclization with trapping chloride ion and an efficient method of the synthesis of <span style="fo...

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Bibliographic Details
Main Authors: Svetlana K. Vorontsova, Anton V. Yadykov, Alexander M. Scherbakov, Mikhail E. Minyaev, Igor V. Zavarzin, Ekaterina I. Mikhaevich, Yulia A. Volkova, Valerii Z. Shirinian
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
interrupted Nazarov cyclization
pentacyclic steroids
antiproliferative activity
<span style="font-variant: small-caps">d</span>-annulated steroids
Lewis acid
Online Access:https://www.mdpi.com/1420-3049/25/15/3499

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https://www.mdpi.com/1420-3049/25/15/3499

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