Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis

Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis

The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease. A consistent neuropathological feature of ALS is the extensive inflammation around motor neurons and axonal degeneration, evidenced...

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Bibliographic Details
Main Authors: Andrés Trostchansky, Mauricio Mastrogiovanni, Ernesto Miquel, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Patricia Cassina, Homero Rubbo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
nitro-fatty acid
ALS
neurodegeneration
inflammation
astrocytes
mass spectrometry
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00131/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00131/full

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