Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate (DOCA)-salt hypertension

Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate (DOCA)-salt hypertension

Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide (NO) production and impairs endothelial function in vascular pathologies. Using a gene deletion model, we investigated involvement of arginase isoforms (1 and 2) in hypertension and endothelial dysfunction in...

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Bibliographic Details
Main Authors: Haroldo A. Toque, Kenia P. Nunes, Modesto eRojas, Anil eBhatta, Lin eYao, Zhimin eXu, Maritza J. Romero, R. Clinton Webb, Ruth B. Caldwell, R. William Caldwell
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Immunology
Subjects:
Arginase
Fibrosis
Hypertension
endothelial dysfunction
DOCA-salt
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00219/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00219/full

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