Genetic Engineering of Lactococcus lactis Co-producing Antigen and the Mucosal Adjuvant 3′ 5′- cyclic di Adenosine Monophosphate (c-di-AMP) as a Design Strategy to Develop a Mucosal Vaccine Prototype

Genetic Engineering of Lactococcus lactis Co-producing Antigen and the Mucosal Adjuvant 3′ 5′- cyclic di Adenosine Monophosphate (c-di-AMP) as a Design Strategy to Develop a Mucosal Vaccine Prototype

Lactococcus lactis is a promising candidate for the development of mucosal vaccines. More than 20 years of experimental research supports this immunization approach. In addition, 3′ 5′- cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger that plays a key role in the regulati...

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Bibliographic Details
Main Authors: Ingrid Quintana, Martín Espariz, Silvina R. Villar, Florencia B. González, Maria F. Pacini, Gabriel Cabrera, Iván Bontempi, Estefanía Prochetto, Jörg Stülke, Ana R. Perez, Iván Marcipar, Victor Blancato, Christian Magni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
Lactococcus lactis
c-di-AMP adjuvant
live vaccine
delivery system
T. cruzi
trans-sialidase
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02100/full

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02100/full

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