APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review

Abstract Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for the sporadic form of Alzheimer’s disease (AD). While researchers have extensively characterized the impact that APOE ε4 (APOE4) has on the susceptibility of AD, far fewer studies have investigated...

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Bibliographic Details
Main Authors: Sheina Emrani, Hirra A. Arain, Cassandra DeMarshall, Tal Nuriel
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
AD
Online Access:http://link.springer.com/article/10.1186/s13195-020-00712-4