Evaluation of a <sup>68</sup>Ga-Labeled DOTA-Tetrazine as a PET Alternative to <sup>111</sup>In-SPECT Pretargeted Imaging

Evaluation of a <sup>68</sup>Ga-Labeled DOTA-Tetrazine as a PET Alternative to <sup>111</sup>In-SPECT Pretargeted Imaging

The bioorthogonal reaction between a tetrazine and strained trans-cyclooctene (TCO) has garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging using an <sup>111</sup>In-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-linked b...

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Bibliographic Details
Main Authors: Patricia E. Edem, Jesper T. Jørgensen, Kamilla Nørregaard, Rafaella Rossin, Abdolreza Yazdani, John F. Valliant, Marc Robillard, Matthias M. Herth, Andreas Kjaer
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
tetrazine ligation
pet
spect
gallium-68
indium-11
Online Access:https://www.mdpi.com/1420-3049/25/3/463

Internet

https://www.mdpi.com/1420-3049/25/3/463

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