Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation.

Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation.

The sialidase activity of neuraminidase-1 (Neu-1) is responsible for ERK 1/2 pathway activation following binding of elastin peptide on the elastin receptor complex. In this work, we demonstrate that the receptor and lipid rafts colocalize at the plasma membrane. We also show that the disruption of...

Full description

Bibliographic Details
Main Authors: Anthony Rusciani, Laurent Duca, Hervé Sartelet, Aurore Chatron-Colliet, Hélène Bobichon, Dominique Ploton, Richard Le Naour, Sébastien Blaise, Laurent Martiny, Laurent Debelle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2982818?pdf=render

Internet

http://europepmc.org/articles/PMC2982818?pdf=render

Similar Items