The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy

The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy

Tumor cells show acidic conditions compared with normal cells, which further inspires scientist to build nanocarrier responsive to tumor microenvironment (TME) for enhancing tumor therapeutic efficacy. Here, we report a pH-sensitive and biocompatible polyprodrug based on dextran-doxorubicin (DOX) pr...

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Bibliographic Details
Main Authors: Xiaoli Zhang, Tian Zhang, Xianbin Ma, Yajun Wang, Yi Lu, Die Jia, Xiaohua Huang, Jiucun Chen, Zhigang Xu, Feiqiu Wen
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Dextran
Chemotherapy
Prodrug
Tumor acidic microenvironment
Controlled release
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087619308323

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http://www.sciencedirect.com/science/article/pii/S1818087619308323

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