Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
Ethylene is a plant hormone that promotes fruit ripening. Here, the authors identify pyrazinamide, a drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis inArabidopsis thalianaand present the crystal structure of its active form (pyrazinecarboxylic acid) bound to ACC oxidase.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15758 |