Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

Abstract Background Glioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive and associated with altered N-glycosylation pattern. Glycocalyx thickne...

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Bibliographic Details
Main Authors: Emilie Marhuenda, Christine Fabre, Cunjie Zhang, Martà Martin-Fernandez, Thomas Iskratsch, Ali Saleh, Luc Bauchet, Julien Cambedouzou, Jean-Philippe Hugnot, Hugues Duffau, James W. Dennis, David Cornu, Norbert Bakalara
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mechanotransduction
3D-nanofibre scaffold
Biomaterial
Stiffness
Glycosylation
Mgat5
Online Access:https://doi.org/10.1186/s13046-021-01925-7

Internet

https://doi.org/10.1186/s13046-021-01925-7

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