Discovery of Amide-Functionalized Benzimidazolium Salts as Potent α-Glucosidase Inhibitors

Discovery of Amide-Functionalized Benzimidazolium Salts as Potent α-Glucosidase Inhibitors

α-Glucosidase inhibitors (AGIs) are used as medicines for the treatment of diabetes mellitus. The α-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars. The process results in an increase in blood sugar levels. AGIs slow down the dig...

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Bibliographic Details
Main Authors: Imran Ahmad Khan, Matloob Ahmad, Usman Ali Ashfaq, Sadia Sultan, Magdi E.A. Zaki
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
benzimidazole derivatives
benzimidazolium salts
molecular docking
anti-diabetic studies
α-glucosidase inhibition
Online Access:https://www.mdpi.com/1420-3049/26/16/4760

Internet

https://www.mdpi.com/1420-3049/26/16/4760

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