High-mannose type N-glycans with core fucosylation and complex-type N-glycans with terminal neuraminic acid residues are unique to porcine islets.

High-mannose type N-glycans with core fucosylation and complex-type N-glycans with terminal neuraminic acid residues are unique to porcine islets.

<h4>Objectives</h4>Islet transplantation is an emerging treatment option for type 1 diabetes but its application is limited by the shortage of human pancreas donors. Characterization of the N- and O-glycan surface antigens that vary between human and genetically engineered porcine islet...

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Bibliographic Details
Main Authors: Yoshihide Nanno, Asif Shajahan, Roberto N Sonon, Parastoo Azadi, Bernhard J Hering, Christopher Burlak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241249

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https://doi.org/10.1371/journal.pone.0241249

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