Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

Abstract Background Genome-wide association studies have established clusterin (CLU) as a genetic modifier for late-onset Alzheimer’s disease (AD). Both protective and risk alleles have been identified which may be associated with its expression levels. However, the physiological function of cluster...

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Bibliographic Details
Main Authors: Fading Chen, Dan B. Swartzlander, Anamitra Ghosh, John D. Fryer, Baiping Wang, Hui Zheng
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Amyloid
Astrocyte
Clusterin
Mice
Synaptic transmission
Online Access:https://doi.org/10.1186/s13024-021-00426-7

Internet

https://doi.org/10.1186/s13024-021-00426-7

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