TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis

Abstract Inflammatory bowel disease (IBD) has a close association with transketolase (TKT) that links glycolysis and the pentose phosphate pathway (PPP). However, how TKT functions in the intestinal epithelium remains to be elucidated. To address this question, we specifically delete TKT in intestin...

Full description

Bibliographic Details
Main Authors: Na Tian, Lei Hu, Ying Lu, Lingfeng Tong, Ming Feng, Qi Liu, Yakui Li, Yemin Zhu, Lifang Wu, Yingning Ji, Ping Zhang, Tianle Xu, Xuemei Tong
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04142-4