Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents

Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823, CT-26, Bel-7402, and MCF-7) of different...

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Bibliographic Details
Main Authors: Xiaofei Chen, Liang Guo, Qin Ma, Wei Chen, Wenxi Fan, Jie Zhang
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/16/2950