FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes.

FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes.

We recently developed a longer lasting recombinant factor VIII-Fc fusion protein, rFVIIIFc, to extend the half-life of replacement FVIII for the treatment of people with hemophilia A. In order to elucidate the biological mechanism for the elongated half-life of rFVIIIFc at a cellular level we deline...

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Bibliographic Details
Main Authors: Arjan van der Flier, Zhan Liu, Siyuan Tan, Kai Chen, Douglas Drager, Tongyao Liu, Susannah Patarroyo-White, Haiyan Jiang, David R Light
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4408089?pdf=render

Internet

http://europepmc.org/articles/PMC4408089?pdf=render

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