Th17 cells inhibit CD8+ T cell migration by systematically downregulating CXCR3 expression via IL-17A/STAT3 in advanced-stage colorectal cancer patients

Th17 cells inhibit CD8+ T cell migration by systematically downregulating CXCR3 expression via IL-17A/STAT3 in advanced-stage colorectal cancer patients

Abstract Background CD8+ T cell trafficking to the tumor site is essential for effective colorectal cancer (CRC) immunotherapy. However, the mechanism underlying CD8+ T cell infiltration in colorectal tumor tissues is not fully understood. In the present study, we investigated CD8+ T cell infiltrati...

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Bibliographic Details
Main Authors: Dan Wang, Weina Yu, Jingyao Lian, Qian Wu, Shasha Liu, Li Yang, Feng Li, Lan Huang, Xinfeng Chen, Zhen Zhang, Aitian Li, Jinbo Liu, Zhenqiang Sun, Junxia Wang, Weitang Yuan, Yi Zhang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Hematology & Oncology
Subjects:
Colorectal cancer
CD8
CXCR3
IL-17A
Th17 cells
Online Access:http://link.springer.com/article/10.1186/s13045-020-00897-z

Internet

http://link.springer.com/article/10.1186/s13045-020-00897-z

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