RNF12 activates Xist and is essential for X chromosome inactivation.

RNF12 activates Xist and is essential for X chromosome inactivation.

In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females. Initiation of random X chromosome inactivation (XCI) is thought to be regulated by X-encoded activators and autosomall...

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Bibliographic Details
Main Authors: Tahsin Stefan Barakat, Nilhan Gunhanlar, Cristina Gontan Pardo, Eskeatnaf Mulugeta Achame, Mehrnaz Ghazvini, Ruben Boers, Annegien Kenter, Eveline Rentmeester, J Anton Grootegoed, Joost Gribnau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3029249?pdf=render

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http://europepmc.org/articles/PMC3029249?pdf=render

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