Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas.

Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas.

A large body of evidence supports a key role for telomere dysfunction in carcinogenesis due to the induction of chromosomal instability. To study telomere shortening in precancerous pancreatic lesions, we measured telomere lengths using quantitative fluorescence in situ hybridization in the normal p...

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Bibliographic Details
Main Authors: Yoko Matsuda, Toshiyuki Ishiwata, Naotaka Izumiyama-Shimomura, Hideki Hamayasu, Mutsunori Fujiwara, Ken-Ichiro Tomita, Naoki Hiraishi, Ken-Ichi Nakamura, Naoshi Ishikawa, Junko Aida, Kaiyo Takubo, Tomio Arai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319908?pdf=render

Internet

http://europepmc.org/articles/PMC4319908?pdf=render

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