Protection of rat primary hippocampal cultures from Aβ cytotoxicity by pro-inflammatory molecules is mediated by astrocytes

Protection of rat primary hippocampal cultures from Aβ cytotoxicity by pro-inflammatory molecules is mediated by astrocytes

The brain of Alzheimer's disease patients shows abundant dystrophic neurites in close proximity to fibrillar β-amyloid (Aβ) plaques, and activated glial cells. We evaluated the influence of pro-inflammatory molecules (LPS + IFN-γ) on Aβ1–42 neurotoxicity. 2 μM Aβ1–42 induced apoptosis of hippoc...

Full description

Bibliographic Details
Main Authors: Gigliola Ramírez, Rodrigo Toro, Heinz Döbeli, Rommy von Bernhardi
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid peptide
Cytotoxicity
Neuroprotection
Astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000069

Internet

http://www.sciencedirect.com/science/article/pii/S0969996105000069

Similar Items