Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats

Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats

Abstract Background Inflammation has been implicated in the development of cardiovascular disease. We determined whether nod-like receptor with pyrin domain containing 3 (NLRP3) involved in the process of prehypertension, central blockade of NLRP3 decreased inflammation reaction, regulated neurohorm...

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Bibliographic Details
Main Authors: Mo-Lin Wang, Yu-Ming Kang, Xiao-Guang Li, Qing Su, Hong-Bao Li, Kai-Li Liu, Li-Yan Fu, Roland Osei Saahene, Ying Li, Hong Tan, Xiao-Jing Yu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Neuroinflammation
Subjects:
NLRP3
Hypothalamic paraventricular nucleus
Inflammation
Neurotransmitters
Microglia
Hypertension
Online Access:http://link.springer.com/article/10.1186/s12974-018-1131-7

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http://link.springer.com/article/10.1186/s12974-018-1131-7

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