Formation of upd(7)mat by trisomic rescue: SNP array typing provides new insights in chromosomal nondisjunction

Formation of upd(7)mat by trisomic rescue: SNP array typing provides new insights in chromosomal nondisjunction

Abstract Background Maternal uniparental disomy (UPD) of chromosome 7 (upd(7)mat) accounts for approximately 10% of patients with Silver-Russell syndrome (SRS). For upd(7)mat and trisomy 7, a significant number of mechanisms have been proposed to explain the postzygotic formation of these chromosoma...

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Bibliographic Details
Main Authors: Sandra Chantot-Bastaraud, Svea Stratmann, Frédéric Brioude, Matthias Begemann, Miriam Elbracht, Luitgard Graul-Neumann, Madeleine Harbison, Irène Netchine, Thomas Eggermann
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Cytogenetics
Subjects:
Maternal uniparental Disomy 7
Formation mechanism
Chromosome 7
Trisomic rescue
Online Access:http://link.springer.com/article/10.1186/s13039-017-0329-1

Internet

http://link.springer.com/article/10.1186/s13039-017-0329-1

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