Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

<h4>Unlabelled</h4>Estradiol 17ß-D-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways...

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Bibliographic Details
Main Authors: Ismael R Barosso, Andrés E Zucchetti, Andrea C Boaglio, M Cecilia Larocca, Diego R Taborda, Marcelo G Luquita, Marcelo G Roma, Fernando A Crocenzi, Enrique J Sánchez Pozzi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209816/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209816/?tool=EBI

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