Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

Communications between actin filaments and integrin-mediated focal adhesion (FA) are crucial for cell adhesion and migration. As a core platform to organize FA proteins, the tripartite ILK/PINCH/Parvin (IPP) complex interacts with actin filaments to regulate the cytoskeleton-FA crosstalk. Rsu1, a Ra...

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Bibliographic Details
Main Authors: Haibin Yang, Leishu Lin, Kang Sun, Ting Zhang, Wan Chen, Lianghui Li, Yuchen Xie, Chuanyue Wu, Zhiyi Wei, Cong Yu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
actin
stress fiber
focal adhesion
HeLa cells
Online Access:https://elifesciences.org/articles/64395

Internet

https://elifesciences.org/articles/64395

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