Single Domain Antibodies Targeting Receptor Binding Pockets of NadA Restrain Adhesion of Neisseria meningitidis to Human Brain Microvascular Endothelial Cells

Single Domain Antibodies Targeting Receptor Binding Pockets of NadA Restrain Adhesion of Neisseria meningitidis to Human Brain Microvascular Endothelial Cells

Neisseria adhesin A (NadA), one of the surface adhesins of Neisseria meningitides (NM), interacts with several cell types including human brain microvascular endothelial cells (hBMECs) and play important role in the pathogenesis. Receptor binding pockets of NadA are localized on the globular head do...

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Bibliographic Details
Main Authors: Amod Kulkarni, Evelína Mochnáčová, Petra Majerova, Ján Čurlík, Katarína Bhide, Patrícia Mertinková, Mangesh Bhide
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
Neisseria
HBMEC = human brain microvascular endothelial cell
phage display
VHH antibodies
adhesin
BBB–blood–brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.573281/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.573281/full

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