Minimum concentration of Amphotericin B in serum according to the formulation, dose, and daily or prolonged intermittent therapeutic regimen

Minimum concentration of Amphotericin B in serum according to the formulation, dose, and daily or prolonged intermittent therapeutic regimen

Abstract INTRODUCTION: The therapeutic efficacy of daily amphotericin B infusion is related to its maximum concentration in blood; however, trough levels may be useful in intermittent regimens of this antifungal drug. METHODS : High performance liquid chromatography (HPLC) was used to determine th...

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Bibliographic Details
Main Authors: Leticia Aparecida Schiave, Erika Nascimento, Gilberto Gambero Gaspar, Fernando Crivelenti Vilar, Edson Zangiacomi Martinez, Cristiane Masetto de Gaitani, Roberto Martinez
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT)
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
amphotericin b
pharmacokinetics
intermittent use
ambulatory therapy
cryptococcal meningitis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100300&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100300&lng=en&tlng=en

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