Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress

Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress

Alcohol consumption is an addictive disorder causing hepatic steatosis, fibrosis and cirrhosis. The protective effect of fisetin, a bioflavonoid, present in foods like strawberries, apples, persimmons, grapes and onions was studied on murine model of acute alcohol-induced hepatotoxicity. Five doses...

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Bibliographic Details
Main Authors: Meghana Koneru, Bidya Dhar Sahu, Jerald Mahesh Kumar, Madhusudana Kuncha, Amrita Kadari, Eswar Kumar Kilari, Ramakrishna Sistla
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Functional Foods
Subjects:
Alcohol-induced acute liver injury
Fisetin
Matrix metalloproteinases (MMPs)
Oxidative stress
Nuclear factor-kappa B (NF-κB)
Online Access:http://www.sciencedirect.com/science/article/pii/S175646461600075X

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http://www.sciencedirect.com/science/article/pii/S175646461600075X

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