The 25 kDa H<sub>CN</sub> Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity

The 25 kDa H<sub>CN</sub> Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity

The extraordinarily potent clostridial neurotoxins (CNTs) comprise tetanus neurotoxin (TeNT) and the seven established botulinum neurotoxin serotypes (BoNT/A-G). They are composed of four structurally independent domains: the roles of the catalytically active light chain, the translocation domain H&...

Full description

Bibliographic Details
Main Authors: Julian Deppe, Jasmin Weisemann, Stefan Mahrhold, Andreas Rummel
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Toxins
Subjects:
botulinum neurotoxin
BoNT/A
BoNT/B
tetanus neurotoxin
H<sub>CN</sub> domain
synaptic vesicle protein
Online Access:https://www.mdpi.com/2072-6651/12/12/743

Internet

https://www.mdpi.com/2072-6651/12/12/743

Similar Items