gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

Abstract Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages. Methods The synthesis of the designed molecules started from easily accessible and versatile gem-difluoro propargylic derivatives. The des...

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Bibliographic Details
Main Authors: Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade, Aida Habib
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Chemistry
Subjects:
Fluorine
Diaryl ethers
Macrophages
Cyclooxygenase
Inflammation
Online Access:http://link.springer.com/article/10.1186/s13065-019-0640-5

Internet

http://link.springer.com/article/10.1186/s13065-019-0640-5

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