Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling

Cinnamaldehyde Derivative (CB-PIC) Sensitizes Chemo-Resistant Cancer Cells to Drug-Induced Apoptosis via Suppression of MDR1 and its Upstream STAT3 and AKT Signalling

Background/Aims: Our group reported that cinnamaldehyde derivative, (E)-4-((2-(3-oxopop-1-enyl)phenoxy)methyl)pyridinium malonic acid (CB-PIC) induced apoptosis in hypoxic SW620 colorectal cancer cells via activation of AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase (E...

Full description

Bibliographic Details
Main Authors: Jianzhong Xi, Miyong Yun, Duckgue Lee, Moon-Nyeo Park, Eun-Ok Kim, Eun Jung Sohn, Byung-Mog Kwon
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
MDR-1
Drug resistance
Apoptosis
Synergy
Online Access:http://www.karger.com/Article/FullText/373993

Internet

http://www.karger.com/Article/FullText/373993

Similar Items