Harnessing PTEN’s Growth Potential in Neuronal Development and Disease

PTEN is a powerful regulator of neuronal growth. It globally suppresses axon extension and branching during both nervous system development and regeneration, by antagonizing growth-promoting PI3K/PI(3,4,5)P 3 signaling. We recently identified that the transmembrane protein PRG2/LPPR3 functions as a...

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Bibliographic Details
Main Authors: Joachim Fuchs, Britta J. Eickholt, George Leondaritis
Format: Article
Language:English
Published: SAGE Publishing 2020-09-01
Series:Neuroscience Insights
Online Access:https://doi.org/10.1177/2633105520959056