Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

3,3′-Diindolylmethane (DIM), a metabolic product of indole-3-carbinol extracted from cruciferous vegetables exhibits anti-inflammatory and anti-cancer properties. Earlier, the product has been demonstrated to possess anti-fibrotic properties; however, its protective effects on liver injury...

Full description

Bibliographic Details
Main Authors: Suvesh Munakarmi, Lokendra Chand, Hyun Beak Shin, Kyu Yun Jang, Yeon Jun Jeong
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
dim
carbon tetrachloride (ccl<sub>4</sub>)
nuclear factor erythroid-2-related factor 2 (nrf2)
hemeoxygenase-1 (ho-1)
inflammation
apoptosis
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/21/6/2048

Internet

https://www.mdpi.com/1422-0067/21/6/2048

Similar Items