Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

Locked nucleic acid (LNA) oligonucleotides have been successfully used to efficiently inhibit endogenous small noncoding RNAs in vitro and in vivo. We previously demonstrated that the direct miR-221 inhibition by the novel 13-mer LNA-i-miR-221 induces significant antimyeloma activity and upregulates...

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Bibliographic Details
Main Authors: Maria Eugenia Gallo Cantafio, Boye Schnack Nielsen, Chiara Mignogna, Mariamena Arbitrio, Cirino Botta, Niels M Frandsen, Christian Rolfo, Pierosandro Tagliaferri, Pierfrancesco Tassone, Maria Teresa Di Martino
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Cynomolgus monkeys
LNA inhibitor
microRNA
miRNA therapeutics
multiple myeloma
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300513

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http://www.sciencedirect.com/science/article/pii/S2162253117300513

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