Ameliorated in vitro anticancer efficacy of methotrexate d-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells

Ameliorated in vitro anticancer efficacy of methotrexate d-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells

Abstract Background Methotrexate (MTX), a folate anti-metabolite, has been used widely in the treatment of plenty of malignancies. However, the clinical use is limited because of its poor water solubility (BCS class II drug), nonspecific distribution, drug resistance, short circulation half-life, an...

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Bibliographic Details
Main Authors: Arehalli S. Manjappa, Popat S. Kumbhar, Rohini Kasabe, Sonali K. Diwate, John I. Disouza
Format: Article
Language:English
Published: SpringerOpen 2019-12-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Methotrexate prodrug
TPGS
Cytotoxicity
Cell cycle analysis and apoptosis
Online Access:https://doi.org/10.1186/s43094-019-0013-x

Internet

https://doi.org/10.1186/s43094-019-0013-x

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