LncRNA-BLACAT1 Facilitates Proliferation, Migration and Aerobic Glycolysis of Pancreatic Cancer Cells by Repressing CDKN1C via EZH2-Induced H3K27me3

LncRNA-BLACAT1 Facilitates Proliferation, Migration and Aerobic Glycolysis of Pancreatic Cancer Cells by Repressing CDKN1C via EZH2-Induced H3K27me3

ObjectiveTo investigate the role of lncRNA-BLACAT1 in promoting H3K27 trimethylation of CDKN1C gene by recruiting EZH2 to regulate CCNE on glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer (PC) cells.MethodsFollowing bioinformatic prediction, EZH2 and BLACAT1 in PC cells we...

Full description

Bibliographic Details
Main Authors: Xin Zhou, Wei Gao, Huanhuan Hua, Zhimin Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
BLACAT1
EZH2
CDKN1C
H3K27
CCNE
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.539805/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.539805/full

Similar Items