Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis

Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis

Abstract Islets transplantation, as a treatment of type 1 diabetes, faces challenges, including the loss of islets in the process of isolation and pre-transplantation due to cellular stresses-induced apoptosis. Accordingly, the optimization of culture plays a decisive role in the transplantation suc...

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Bibliographic Details
Main Authors: Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Bita Geramizadeh, Elahe Motevaseli, Saman Nikeghbalian, Alireza Shamsaeefar, Nasrin Motazedian, Ismail H. Al-Abdullah, Mohammad Hossein Ghahremani, Negar Azarpira
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-48262-6

Internet

https://doi.org/10.1038/s41598-019-48262-6

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